Continuous infusion of fluorouracil lasting 240 hours in 35 cases with gastric cancer
- VernacularTitle:氟尿嘧啶持续滴注240小时治疗35例胃癌
- Author:
Qianlang XU
;
Xueyuan JI
;
Junxing HUANG
- Publication Type:Journal Article
- Keywords:
gastric neoplasms;
fluorouracil;
continuous infusion
- From:
China Oncology
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the clinical response and the toxic-side reactions of patients with gastric cancer treated with continuous infusion of fluorouracil (5-FU) lasting 240 hours.Methods:35 cases of gastric cancer were treated with continuous infusion of 5-FU lasting 240 hours.32 cases of gastric cancer were treated with traditional infusion of 5-FU on days 1 to 5. The clinical response and the toxic -side reactions were observed.Results:35 cases were treated with continuous infusion of 5-FU regimen with a response rate of 51.4%. 32 cases were treated with traditional infusion of 5-FU regimen with a response rate of 25.0%,thus between them,there was a significant difference in curative effects. The toxicities in traditional infusion of 5-FU group were more severe than in continuous infusion of 5-FU group. They included myelosuppression nausea et al.Conclusions:Continuous infusion of 5-FU regimen is preferable in the treatment of gastric cancer.
