Advances in research on the expression of matrix metalloproteinases in gastrointestinal cancer and their inhibitors in treatment
- VernacularTitle:基质金属蛋白酶在胃肠癌中的表达及其抑制剂的研究进展
- Author:
Yueguang DU
;
Weizhe CHEN
- Publication Type:Journal Article
- Keywords:
gastrointestinal neoplasms;
matrix metalloproteinases;
matrix metalloproteinase inhibitor;
treatment
- From:
China Oncology
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Matrix metalloproteinase (MMP) are a family of zinc-dependent endoproteinases whose enzymatic activity is directed against components of the extracelluar matrix(ECM). Their activities are inhibited by the tissue inhibitor of metalloproteinase (TIMP). MMP exerted an important role in invasion and metastasis of gastrointestinal cancer through degrading the ECM. With further research on inhibition of MMP, synthetic MMP inhibitor will have good prospects in the treatment of tumor invasion and metastasis.
