The comparison and significance of the glucocorticoid receptors of the peripheral leukocytes in patients with acute spinal cord injury or with chronic spinal cord compression
- VernacularTitle:不同类型脊髓损伤患者外周血白细胞糖皮质激素受体的比较及意义
- Author:
Hong ZHAO
;
Lianshun JIA
;
Jie WANG
- Publication Type:Journal Article
- Keywords:
Spinal cord compression;
Glucocorticoids;
Receptors, glucocorticoid;
Leukocytes
- From:
Chinese Journal of Orthopaedics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the difference and significance of the glucocorticoid receptors of the peripheral leukocytes in patients with acute spinal cord injury or with chronic spinal cord compression. Methods Glucocorticoid receptors binding sites on the peripheral leukocytes in 20 patients with acute spinal cord injury and 21 patients with chronic spinal cord compression were measured by the radioligand binding assay. Results Glucocorticoid receptors binding sites on peripheral leukocytes from the patients with acute spinal cord injury is 2 517?857.8 per cell, the patients with chronic spinal cord compression is 4 225?1 271 per cell and outcome is 2 279?921 per cell in the patients with complete paralysis, 2 806?718 per cell in the incomplete paralysis patients. T test was used to evaluate the final outcome. Conclusion Glucocorticoid receptors binding sites on the peripheral leukocytes consist of two kinds: the high affinity binding sites and the low affinity binding sites. The high affinity glucocorticoid receptors binding sites on peripheral leukocytes in patients with acute spinal cord injury decrease and low affinity binding sites remain unchanged. Large doses of glucocorticoid combine the low affinity binding sites on peripheral leukocytes which inhibits the tendency of movement of leukocytes to the injured spinal cord; so inflammatory reaction produced by acute injury can be alleviated and thus the spinal cord was protected. There is no curative effect by using large doses of glucocorticoid to treat patients with chronic spinal cord compression.
