Study on mitochondrial DNA gene tRNA~(Leu(UUR))A3243G mutation in patients with below-40-year-old-onset diabetes mellitus in China
- VernacularTitle:中国40岁以下发病的糖尿病患者线粒体基因tRNA~(Leu(UUR))A3243G突变的研究
- Author:
Shinan YIN
;
Changyu PAN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, non-insulin-dependent;
DNA, mitochondrial;
Mutation
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics and the prevalence of mitochondrial gene A3243G mutation in patients with below-40-year-old-onset type 2 diabetes mellitus in China. Methods Body mass index (BMI), waist hip ratio (WHR), metabolism control, insulin secretion and HOMA-IR were determined in 207 patients with below-40-year-old-onset diabetes mellitus and 50 subjects with normal OGTT as control. There were 117 cases with diabetic family history. The mitochondrial gene A3243G mutation was assayed by PCR-RFLP. Results TherewasnosignificantdifferenceofBMI〔(25.1?3.1) vs (24.1?3.4)kg/m 2〕 between two diabetic subgroups. The fasting blood glucose (FBG) and HbA 1c were both higher in two diabetic subgroups. Inthosepatientstheinsulin resistance was obviously (HOMA-IR 3.41～9.29). The mitochondrial gene A3243G mutation was found in one case and 5 members of her family (three cases had diabetes mellitus and two cases had normal glucose tolerance). Conclusion The prevalence of the mitochondrial gene A3243G mutatuion is 0.48% in early onset diabetic patients in China and 0.85% in positive diabetic family history patients.
