The safety and efficacy of aricept in patients with Alzheimer disease
- VernacularTitle:安理申治疗轻中度阿尔茨海默病有效性及安全性的临床研究
- Author:
Dantao PENG
;
Xianhao XU
;
Qingyun HOU
- Publication Type:Journal Article
- Keywords:
Indans;
Piperidines;
Alzheimer disease
- From:
Chinese Journal of Neurology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy and safety of aricept in treatment of mild to moderate Alzheimer disease(AD).Methods 188 patients with AD were followed up in a multicentre,with randomized study for 12 weeks. 89 patients had a single -blind,placebo-controlled trial and 99 a self-matched trial.Results The results of randomized single-blind,placebo-controlled trial showed that the improvements in MMSE、CDR and ADL were statistically significantly greater with aricept 5 mg/d than with placebo(P value respectively 0.05).Conclusion Aricept is effective in treating patients with mild to moderate AD. It could produce improvements in cognition and ability of daily life. Aricept was well tolerated and safe.
