Influence of matrine on the cell cycle and DNA content of fibroblasts derived from hypertrophic scar
- VernacularTitle:苦参碱对人增生性瘢痕成纤维细胞细胞周期和DNA含量的影响
- Author:
Suyang TANG
;
Huorong XU
;
Qiang WANG
- Publication Type:Journal Article
- Keywords:
Matrine;
Fibroblast;
Cell cycle;
DNA Content
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2002;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of matrine on the cell cycle and DNA content of fibroblasts derived from hypertrophic scarring tissues. Methods The fibroblasts were derived from 3～5 generations of the cultured hypertrophic scarring tissues. After the cells were treated with different concentration of matrine, the population doubling time was calculated and the cell cycle and DNA content were measured with flow cytometry. The fibroblasts treated with normal saline were as control. Results Compared with the control group, the distributions in cell cycle showed that the percentage of G 2 M and S phase cells decreased, and the percentage of G 0 G 1 phase cells increased significantly ( P
