The changes of dopamine D1 and D2 receptors in the striatum of Parkinsonian mice induced by paraquat
- VernacularTitle:百草枯致帕金森病模型小鼠脑纹状体多巴胺D1、D2受体变化
- Author:
Jinpeng REN
;
Huimin REN
;
Yuping JIANG
- Publication Type:Journal Article
- Keywords:
Paraquat;
Parkinson disease;
Receptor, dopamine
- From:
Chinese Journal of Geriatrics
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore whether the dopamine D1 and D2 receptors were involved in pathogenic mechanism of Parkinsonian mice induced by paraquat. Methods The models of Parkinson's mice were induced by oral paraquat. The levels of dopamine D1 and D2 receptor proteins and the expression of receptor mRNAs in striatum were examined by immunohistochemistry and in situ hybridization, respectively. Results Mice treated by oral paraquat (10mg?day -1 ?kg -1 ) for four months displayed marked hypoactive behavior. The levels of dopamine D1 and D2 receptor proteins in the striatum were significantly decreased by 28% and 29%, respectively (P
