Interleukin-1 receptor antagonist reduces interleukin-1 induced interleukin-6 production in human gingival fibroblasts
- VernacularTitle:IL-lra对IL-1?诱导人牙龈成纤维细胞分泌IL-6的拮抗作用
- Author:
Huaixiu LU
;
Yabin KANG
;
Zhongying NIU
- Publication Type:Journal Article
- Keywords:
Interleukin l;
Receptor antagonist;
Interleukin 6;
Gingival;
Fibroblasts
- From:
Journal of Practical Stomatology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
砄bjective: To determine the effects of interleukin 1 receptor antagonist( IL lra) on the production of IL 6 induced by IL 1? in human gingival fibroblasts(HGFs). Methods:HGFs at passage 5 were exposed to various concentrations of IL 1? with or without IL 1r? . IL 6 in the culture medium was measured with a sandwish ELISA assay. Results:IL 6(?g/L) produced by HGFs exposed to IL 1? at the concentrations (?g/L) of 0.1, 1.0, 10 and 100 were 207?40.29, 235?80.78, 370?40.62, 570?68.17 and 737.5?83.47 respectively. While that by HGFs exposed to IL 1? at 10 ?g/L with IL 1r?(?g/L) at 1, 10, 100 and 1 000 were 387.5?49.69, 312.5?26.81, 242.5?25.86 and 217.5?21.65 respectively. Conclusion: IL lra can inhibite the IL 1? induced IL 6 production in HGFs.
