Human telomerase reverse transcriptase(hTRT) mRNA expression in squamous cell carcinoma and the relationship between hTRT and PCNA expression
- VernacularTitle:口腔鳞癌中hTRT mRNA的表达及其与PCNA关系的探讨
- Author:
Yan CHEN
;
Shaozhong DONG
;
Lianjia YANG
- Publication Type:Journal Article
- Keywords:
Human telomerase reverse transcriptase;
Proliferation cell nuclear antigen;
Mouth;
Squamous cell carcinoma;
Telomerase
- From:
Journal of Practical Stomatology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
砄bjective: To investigate Human telomerase reverse transcriptase(hTRT) mRNA expression in oral squamous cell carcinoma(OSCC) and the relationship between hTRT activity and proliferation cell nuclear antigen(PCNA) expression.Methods: The expression of hTRT mRNA and PCNA was detected by in situ mRNA hybridization and immuno histochemical technique in 52 cases of OSCC and 22 cases of OSCC adjacent tissues including histologically normal mucosas and dysplastic lesions. Results: hTRT mRNA was observed in 82.7% cases of OSCC, 41.7% of dysplasia and 20% of normal mucosa( P
