Investigation on immune tolerance induced by portal venous inoculation of donorspleen cells combined the CsA
- VernacularTitle:门静脉注射供体脾细胞联合应用环孢素A诱导免疫耐受的实验研究
- Author:
Guangchen ZHOU
;
Shuliang XIE
;
Jiacun CHEN
- Publication Type:Journal Article
- Keywords:
Immune tolerance Heart transplantation Cytokine
- From:
Chinese Journal of Immunology
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
With the hereotopic heart transplantation, immune tolerance induced by portal venous inoculation of donor spleen cells was studied.Methods:The recipient rats received donor spleen cells through portal vein combined with of cyclosporine A(CsA).The NK cell activity and IL-2, IFN-y expression of recipient spleen cells were detected. Results: Hie inoculation of donor spleen cells through the portal vein could significandy prolong survival time of heart allografts.IL- 2, IFN-y expression of recipient spleen lymphocytes and the recipient NK cell activity was also inhibitied.Conclusion:The inoculation of donor spleen cells through the portal vein could induce immune tolerance.The suppression of IL-2-NK-IFN-y immunologic net may be an important mechanism of portal vein tolerance.
