Assessment of Abdominal Fat and Mid-Thigh Low-Density Muscle Areas in Patients with Schizophrenia.
- Author:
Chul Sik KIM
1
;
Yoon Young NAM
;
Jong Suk PARK
;
Hai Jin KIM
;
Tae Woong NOH
;
Ji Sun NAM
;
Chul Woo AHN
;
Kyung Rae KIM
;
Kyung Ryeol CHA
;
Chan Hyung KIM
Author Information
1. Department of Endocrinology, Yonsei University College of Medicine, Seoul, Korea. acw@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Abdominal fat;
Mid-thigh low-density muscle;
Insulin resistance;
Type 2 diabetes
- MeSH:
Abdominal Fat*;
Adipose Tissue;
Body Mass Index;
Diabetes Mellitus, Type 2;
Humans;
Insulin Resistance;
Intra-Abdominal Fat;
Male;
Obesity, Abdominal;
Prevalence;
Risk Factors;
Schizophrenia*;
Subcutaneous Fat;
Waist Circumference
- From:Korean Journal of Psychopharmacology
2007;18(2):81-85
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Patients with schizophrenia are at a higher risk for developing insulin resistance and type 2 diabetes mellitus (T2DM). However, few studies have examined abdominal fat and mid-thigh low-density muscle areas, which are known risk factors for insulin resistance and T2DM, in patients with schizophrenia. Therefore, we measured the abdominal fat and mid-thigh low-density muscle areas of schizophrenics and compared them with normal controls. METHODS: Nineteen (four men and 15 women) drug-naive or -free subjects who met the DSM IV criteria for schizophrenia and 19 age- and sex-matched controls were recruited. We measured weight, height, waist circumference, and percent body fat, and calculated the body mass index (BMI). Abdominal fat and mid-thigh low-density muscle areas were evaluated using computed tomography. RESULTS: There was no significant difference in terms of age and BMI between the two groups. The areas of abdominal fat (262.4+/-101.8 vs. 257.1+/-93.8 cm2 ; p=0.919), subcutaneous fat (182.4+/-72.8 vs. 180.5+/-75.1 cm2 ; p=0.988), visceral fat (79.9+/-47.2 vs. 76.6+/-49.3 cm2 ; p=0.872), and mid-thigh low-density muscle (15.0+/-9.9 vs. 15.4+/-5.2 cm2, p=0.373) did not differ between schizophrenics and controls. CONCLUSION: Abdominal obesity is a well-recognized risk factor for developing certain medical conditions such as insulin resistance and T2DM. We demonstrated that drug-naive or- free patients with schizophrenia do not have increased visceral fat or mid-thigh low-density muscle areas, which might have explained the higher prevalence of insulin resistance and T2DM in these patients.
