Monoclonal origin of multifocal urothelial carcinoma
- VernacularTitle:多发性尿路上皮肿瘤的单克隆起源
- Author:
Jiangping GAO
;
Yuezeng WANG
;
Yong XU
- Publication Type:Journal Article
- Keywords:
Urologic neoplasms;
Carcinoma;
Genes;
Clone
- From:
Chinese Journal of Urology
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clonal origin of malignant cells in multifocal urothelial carcinoma. Methods p53 protein expressions were detected by immunohistochemistry in 22 pieces of tumor tissues from 10 patients with urothelial neoplasms.Mutation in p53 was inferred on the basis of immuno staining . Results The p53 protein expression of various tumors in the same patient completely matched, reflecting that the gene status of the multifocal tumor being the same. Conclusions The results strongly support the view that multifocal urothelial tumors are derived from the monoclonal cell.
