Gemcitabine in the treatment of 8 cases with advanced liver cancer
- VernacularTitle:吉西他滨治疗8例晚期肝癌
- Author:
Zhangshu CHEN
- Publication Type:Journal Article
- Keywords:
gemcitabine;
cisplatin;
liver cancer
- From:
China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate the efficacy of gemcitabine for treatment of advanced liver cancer (stage Ⅲ) and its side-effects.Methods:The diagnosis of 8 patients evaluated with cytology and CT,MRI or colour doppler were confirmed as advanced liver cancer (stage Ⅲ). All patients were male with a medium age of 48 years (35-64). The KPS≥50 with normal function of marrow, liver and kidney. Multiple cancer complicated with portal cancer embolization were confirmed which were the contraindication for surgery and TAIE. Gemcitabine was used intravenously infusion for 30 min with a dose of 100 mg/m 2 at day 1,8,15. Cisplatin was used infused intravenously with a dose of 50 mg/m 2 at day 2,3,4. Twenty eight days were counted as one cycle. After 2 cycles of the treatment the efficacy and clinical symptoms were evaluated. Results:Of the 8 patients, 7 were evaluable for treatment outcome. Three obtained PR (42.9%) 3 NR (42.9%). The symptoms related to liver cancer improved after 1-2 cycles of treatment. These improvement could be observed in 57 1% (4/7) for 1 cycle and 85.7% (6/7) for 2 cycles. Conclusions:Combination of gemcitabine with cisplatin was an effective and new chemotherapy for advanced liver cancer, especially for patients with metastasis, relapse and multiple cancer foci. The symptoms related to liver cancer improved after administration of gemcitabine plus cisplatin and the side-effects were tolerable.
