HLA-DPB1, DQB1 genes and their correlation with autoantibodies in type 1 diabetes mellitus
- VernacularTitle:1型糖尿病HLA-DPB1、DQB1基因与其自身抗体相关性研究
- Author:
Wanjia XING
;
Shenglan ZHANG
;
Bingshen KE
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, insulin-dependent;
HLA-DP antigens;
HLA-DQ antigens;
Autoanti-bodies
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate HLA-DPB1, DQB1 gene alleles and their correlation with autoantibodies in type 1 diabetes mellitus. Methods Sequence-based typing was used to determine the alleles of HLA-DPB1 and -DQB1 in 68 patients with type 1 diabetes and 50 healthy controls. Autoantibodies 〔glutamic acid decarboxylase antibody (GADA), islet cell antibody (ICA), insulin autoantibody (IAA)〕were detected by ELISA. Results Compared with the controls, the frequencies of DPB1*0402 and DQB1*0301 were significantly lower in type 1 diabetics (11.76%, 5.15% vs 30.00%, 22,00% respectively, P
