Comparison of the promoting effect on proliferation by secretory-and transmem-brane transforming growth factor-a
- VernacularTitle:跨膜型TGF?与分泌型TGF?增殖作用异同的比较
- Author:
Kan JIANG
;
Zhuoya LI
;
Xiaodan JIANG
- Publication Type:Journal Article
- Keywords:
s-TGFa TM-TGFa Proliferation IL-6mRNA PCNA
- From:
Chinese Journal of Immunology
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Abstract Objective:The effects of both TM-TGFa and S-TGFa on proliferation were compared to explore the biological characteristics of the two forms of TGF-a.Methods:The proliferation of mouse fibroblast cell line NIH3T3 and its expression of PCNA were determined by the methods of MTT and histochemical technique. The level of IL-6 mRNA in HaCaT cell line was tested by in situ hybridization. Results:The two forms of TGFa were able to promote cell proliferation,PCNA expression and IL-6 mRNA transcription.The effects of S-TGFa had been shown stronger than that of TM-TGFa( P
