The research of GST-? gene expression in breast cancer and axillary lymphnodes tis-sues
- VernacularTitle:胎盘型谷胱甘肽转移酶基因在乳腺癌及腋窝淋巴结组织中的表达
- Author:
Jimei LI
;
Hongmei FU
;
Guijun LU
- Publication Type:Journal Article
- Keywords:
GST-? Breast carcinoma Immunohistochemistry RT-PCR
- From:
Chinese Journal of Immunology
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Abstract Objective:To study GST-? expression in breast cancer and axillary lymphnodes.Methods: The expression of GST-Tr proteinand mRNA was detected by means of immunohistochemistry and RT- PCR. Results: In normal breast tissue, cancer tissue , HE positive lymph-nodes and HE negative lymphnodes , GST-? protein expression rate is 0,60% ,77% ,43%; GST-? mRNA expression rate is 0,88% ,71%and 39% , respectively. Conclusion; GST-?gene whose expression is upregulated as tumor occurs and develops can be used as a tumor biomar-ker; GST-? expression in HE negative lymphnodes suggests the poor prognosis; drug-resistance response is more sensitive in lymphnode than inprimary cancer. The expression of GST-? gene may be regulated by RNA or before RNA transcription.
