The increase of 3-nitrotyrosine in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis
- VernacularTitle:散发性肌萎缩侧索硬化病人脑脊液中3-硝基酪氨酸水平增高
- Author:
Ming LU
;
Dongsheng FAN
;
Dexuan KANG
- Publication Type:Journal Article
- Keywords:
Amyotrophic lateral sclerosis;
Tyrosine;
Cerebrospinal fluid
- From:
Chinese Journal of Neurology
1999;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the concentration of 3-nitrotyrosine and tyrosine and the ratio of 3-nitrotyrosine/tyrosine in the cerebrospinal fluid (CSF) of patients with sporadic amyotrophic lateral sclerosis (SALS) and those with healthy nervous system for definiting the role of free radicals oxidative damage in pathogenesis of SALS. Methods Subjects consisted of 15 patients with SALS and 15 patients with norml nervous system who underwent lumbar anesthesia for surgery. Their CSF was analyzed by using high performance liquid chromatography (HPLC). Results The 3-nitrotyrosine concentration was higher in patients with SALS (228.52?124.30 nmol/L) than that in controls (112.86?47.10 nmol/L) (P
