Expression and clinical implication of CC chemokines and receptor in long-term survived renal transplant recipients
- VernacularTitle:肾移植长期存活受者外周血CC家族趋化因子及其受体表达的临床意义
- Author:
Xiao GU
;
Xiaoda TANG
;
Jiaquan XIAO
- Publication Type:Journal Article
- Keywords:
Kidney;
Transplantation;
Immunology;
Chemotactic factors;
Receptor
- From:
Chinese Journal of Urology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical implication of CC chemokines and receptor in long surviving kidney grafted patients of different immune states. Methods 73 cases of recipients surviving more than 3 years were divided into three groups: control group of normal renal function(C group,n=32), group under low dosage of immunosuppressants(L group,n=20) and group with chronic allograft dysfounction(D group,n=21). The plasma RANTES、MCP 1 and MIP 1?were detected by sandwich ELISA.The expression of CCR5 was determined by flow cytometry(FACS). Results Concentrations of RANTES and MIP 1? as well as expression rate of CCR5 in L group were lower than those of C group ( P 0.05).Plasma level of MCP 1 was significantly higher in group D than that in group C( P 0.05). Conclusions Expression of CC chemokines and receptor closely correlated with the immune state of renal transplant recipients and could be valuable to estimate and monitor the immune state of patients.
