Apoptosis of bladder cancer cells induced by oligonucleotide telomerase inhibitor
- VernacularTitle:抑制端粒酶活性诱导膀胱癌细胞凋亡的研究
- Author:
Yongsheng SONG
;
Wei YANG
;
Weijun FU
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Carcinoma;
Telomerase;
Cell apoptosis
- From:
Chinese Journal of Urology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the potential effects of telomerase inhibitor on the apoptosis of bladder cancer cells. Methods A phosphorothioate oligonucleotide (PS ODN) with sequence 5′ d(TTAGGG) 3′, as the telomerase inhibitor, was incubated with a bladder cancer cell line EJ. Such treated cells were studied with many approaches for the telomerase activity, the growth status and the morphological changes. Results The PS ODN inhibited the telomerase activity in the cells, arrested the cell growth, and induced the apoptosis of the cells. Conclusions The apoptosis of bladder cancer cells could be induced by PS ODN with 5′ d(TTAGGG) 3′ sequence as a telomerase inhibitor.
