Influence on cellular apoptosis and telomerase activity in bladder cancer treated with BCG-CWS and IL-2
- VernacularTitle:卡介苗细胞壁骨架加白细胞介素2膀胱灌注对肿瘤细胞凋亡及端粒酶活性的影响
- Author:
Zike QIN
;
Hua MEI
;
Yuping DAI
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Bacillus Calmett Guerin;
Interleukin 2;
Apoptosis;
Telomerase
- From:
Chinese Journal of Urology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the cellular apoptosis and telomerase activity in bladder cancer before and after treatment with cell wall skeleton of bacillus Calmett Guerin(BCG CWS) and interleukin 2(IL 2). Methods The cellular apoptosis and telomerase activity of 33 cases of bladder cancer tissues were detected by terminal deoxynucleotidyl transferase mediated dUTP biotin nick end labeling(TUNEL) and telomeric repeat amplification protocol(TRAP) assay both before and after treated with BCG CWS and IL 2. Results The apoptosis index for bladder cancers before and after treatment with BCG CWS and IL 2 was (35.6?12.7)% and (79.1?11.3)% respectively, the apoptosis index being obviously increased after the treatments, P
