Studies on the pharmacokinetics of the intravesical instillation of mucous adhesive anticancer agent hydroxypropylcellulose-mitomycin C
- VernacularTitle:羟丙基纤维素-丝裂霉素C膀胱灌注的药代动力学研究
- Author:
Siwei ZHOU
;
Guofang ZHAO
;
Xiaodong SONG
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Carcinoma;
Perfusion;
Drug evaluation
- From:
Chinese Journal of Urology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the drug retention of HPC MMC in bladder after intravesical instillation. Methods The pharmacokinetics of the intravesical mucous adhesive anticancer agent HPC MMC in urine and in tissue were comparatively studied with conventional mitomycin C aqueous solution(S MMC) by means of animal experiment. Results After instillation, the half life of MMC in urine in the 2 groups was 2.61 h and 0.56 h and in tissue 2.33h and 0.46 h respectively. Conclusions Suggesting that HPC MMC remained longer within the urinary bladder. It may be therapeutically more efficient.
