Study of the effects of bFGF during the process of osteoblasts allografting to accelerate the fracture healing of osteoporosis rats
- VernacularTitle:成骨细胞移植在促进骨质疏松性骨折愈合过程中细胞生长因子表达特点
- Author:
Jing ZENG
;
Dongliang XU
;
Jushi QIU
- Publication Type:Journal Article
- Keywords:
Osteoporosis;
Osteoblast;
Fibroblast growth factor, basic
- From:
Chinese Journal of Geriatrics
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the biological functions of growth factors in the process of osteoblasts allografting and its acceleration in fracture healing in osteoporosis rats. Methods The fracture model of rat osteoporosis was established and then cell grafting was performed. Immunnohistochemistry and in situ hybridization were utilized to examine the expression of bFGF and bFGF mRNA during the process of fracture healing, the image was also analyzed. Results In the experimental group, bFGF positive cells were seen after 7 days after cell grafting, and peaked in chondrocytes about 14 day (384 65?8 60) after grafting. bFGF began declining after 21 days (286 24?2 30) and disappeared after 56 days. However in the control group, obvious high quanty was not seen and being only 125 33?4 50 even peaked at 21st day. Conclusions bFGF not only plays a very important role in bone formation but also enhances circulation formation in the fracture areas. It also accelerates the fracture healing in osteoporosis rats.
