Inhibitory effect of pravastatin on the pathogenesis of atherosclerotic lesions and the expression of intercellular adhesion molecule-1 in the aortic wall of apoE deficient mice
- VernacularTitle:普伐他汀对apoE缺陷小鼠主动脉粥样硬化及主动脉壁细胞间粘附分子-1表达的影响
- Author:
Xinchao ZHANG
;
Chengbin XU
;
Shengxun WANG
- Publication Type:Journal Article
- Keywords:
Pravastatin;
Apolipoproteins E;
Atherosclerosis;
Vascular cell adhesion molecule 1
- From:
Chinese Journal of Geriatrics
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective In order to understand the mechanisms beyond lipid regulation of 3 hydroxy 3 methyl glutaryl coenzyme A(HMG CoA) reductase inhibitors in anti atherosclerosis, we observed the influence of pravastatin on the pathogenesis of atherosclerotic lesions and the expression of intercellular adhesion molecule (ICAM) 1 in aortic wall of the apoE deficient mice. Methods Pravastatin(10 mg?kg?d -1 ) was fed to 10 , 20 , and 30 week old male apoE deficient mice respectively for 4 weeks. The atherosclerotic plaque size and the ratio of plaque area to aortic luminal area (PA/LA) were determined by histochemical staining and analyzed quantitatively. The expression of ICAM 1 in aortic wall of apoE deficient mice was detected by immunohistochemistry and Western blotting. Results Compared with controls, pravastatin delayed the plaque formation in apoE deficient mice 〔(161 786 1?38 041 2) ?m 2 vs (99 127 9?13 600 3) ?m 2, P
