The preliminary study on the machenism of uptaking of very low density lipoprotein by monocyte-macrophage cells
- VernacularTitle:单核巨噬细胞摄取极低密度脂蛋白机制的初步研究
- Author:
Maoqin SHU
;
Zuoyun HE
;
Jianxin ZHOU
- Publication Type:Journal Article
- Keywords:
Macrophages;
Lipoprotein, VLDL;
Foam cell;
Receptors, lipoprotein
- From:
Chinese Journal of Geriatrics
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The processes responsible for the uptake of very low density lipoprotein(VLDL) by monocyte macrophage cells were investigated. Methods The effects of VLDL concentration, apoE ligand activity and scavenger receptor A (SRA) on the binding of 125 I VLDL to monocyte macrophages were analysed. The influence of VLDL on SRA mRNA and protein expression and VLDL receptor gene translation was probed. Results (1) The differentiated monocyte macrophages induced 125 I VLDL uptake by dose dependent pathway( r =0 71, P
