The survival and migration of Schwann cells after peripheral nerve grafted into spinal cord
- VernacularTitle:带蒂神经植入脊髓后许旺细胞的存活与迁移
- Author:
Qingshan GUO
;
Aimin WANG
;
Hongzhen SUN
- Publication Type:Journal Article
- Keywords:
Peripheral nerve;
Schwann cell;
Graft;
Spinal cord;
Injury
- From:
Chinese Journal of Microsurgery
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the survival of Schwann cells and the effects of induce axon regeneration after peripheral nerve grafted into spinal cord Methods A total of 30 adult,female Wistar rats were used in this study,and a 5 mm cord defect of the left lateral column was made at T 1 3 vertebral level The defect was grafted randomly using vascularized (group VN) or free peripheral nerve (group PN) respectively 8 weeks after surgery,the survival and proliferation of Schwann cells were assessed by histological,histomorphometric analysis Results In group VN,peripheral nerve segment was well innervated,plenty of Schwann cells were survived and proliferated In this group,anti NF,S 100 positives fibers were significantly greater than group PN Conclusion The vascularized peripheral nerve could prompt the survival and proliferation of Schwann cells and support the regeneration of central injured axons to certain degrees
