The change of serum insulin-like growth factor-Ⅰlevel in senile patients with type 2 diabetes mellitus after regular insulin therapy
- VernacularTitle:老年2型糖尿病患者胰岛素治疗后胰岛素样生长因子Ⅰ的变化
- Author:
Hong ZHAO
;
Chenya WANG
;
Yu DUAN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, non insulin dependent;
Insulin like growth factor Ⅰ;
Insulin
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of serum insulin like growth factor Ⅰ (IGF Ⅰ) level in newly diagnosed senile patients with type 2 diabetes mellitus (DM) before and after regular insulin (RI) therapy. Methods Body mass index, blood pressure (BP), 24 hour urinary microalbumin (24hUAlb), fasting blood glucose (FBG), 2 hour postprandial blood glucose (P2hBG), serum insulin (Ins) and C peptide (C P), HbA 1c and IGF Ⅰ were measured in 60 senile type 2 DM patients newly diagnosed by oral glucose tolerance test (OGTT) and 40 healthy senile subject (controls); RI 8 U, 6 U, 6 U were injected to type 2 DM patients before three meals respectively. Two days later, above tests were repeated. Insulin resistance index (IR) was calculated. Results The serum IGF Ⅰ levels were (349.0?49.5)?g/L in control group, (231.8?64.4)?g/L and (294.2?46.2)?g/L in patient group before and after RI therapy, The IGF Ⅰ level was significantly lower before RI therapy than that of controls (P
