Bipolar Diathesis in Patients with Treatment-Resistant Depression.
- Author:
Young Sup WOO
1
;
Won Myong BAHK
Author Information
1. Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea. wmbahk@catholic.ac.kr
- Publication Type:Review
- Keywords:
Treatment-resistant depression;
Bipolarity;
Bipolar spectrum disorder
- MeSH:
Bipolar Disorder;
Comorbidity;
Depression;
Disease Susceptibility;
Humans;
Prevalence;
Risk Factors
- From:Korean Journal of Psychopharmacology
2009;20(5):231-236
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Despite the availability of numerous options for the treatment of depression, treatment-resistant depression remains common. Several patient-related and treatment-related risk factors have been identified as increasing the likelihood of nonresponsiveness to antidepressant treatment including psychiatric and physical comorbidity, the chronic subtype of depression, and treatment nonadherence. Evidence linking many cases of treatment-resistant depression with a diathesis to bipolar disorder has also emerged. This article reviews the current literature regarding the relevance of bipolarity to treatment-resistant depression, with particular attention to the prevalence of bipolarity in treatment-resistant depression.
