CARDIOTONIC EFFECT OF Cl-914 ON ISOLATED GUINEA PIG ATRIA
- VernacularTitle:新型强心药CI-914对离体豚鼠心房的作用
- Author:
Kemin GU
- Publication Type:Journal Article
- Keywords:
cardiotonic agent;
CI-914;
imazodan;
isoprenaline;
aminophylline;
guinea pig;
isolated atria
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Cardiotonic effect of CI-914 (Imazodan), a PDE-inhibitor, was studied on isolated guinea pig atria and compared with that of isoprenaline(ISO)and amino-phylline (AP).The electrically-paced left atria were used to determine their inotroplc effects, wh:;le the spontaneously beating right atria were used to determine their chronotropic ones.Both ISO and CI-914 showed a significant concentration-dependent positive inotropic effect with similar maximal effects(efficacy), though their potencies were quite different(the pD2 of the former was 7.7 and the latter, 4.7).AP also showed a positive inotropic effect but insignificantly.Both ISO and AP showed a significant concentration-depenednt positive chronotropic effect, and CI-914 tended also to increase heart rate but insignificantly.The extracellular calcium concentration-positive inotropic effect curve could be shifted to the left by CI-914.It is suggested that CI-914 could promote calcium influx through calcium-channels, which is probably one of the mechanisms responsible for the cardiotonic action of CI-914.
