Effects of alendronate on trabecular bone structural properties
- VernacularTitle:阿仑膦酸钠对骨小梁结构特性的作用
- Author:
Jianhua HU
;
Gongyi HUANG
;
Ming DING
- Publication Type:Journal Article
- Keywords:
Diphosphonates;
Bone and bones;
Bone density
- From:
Chinese Journal of Orthopaedics
1996;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate alendronate with regards to its effect s on trabecular bone structural properties. Methods Alendronate was administered at a daily p.o. dose of 0.5 mg?kg－1?d－1 over a 12 weeks period in Hound do gs (n=8 ＋ 8 for control and treated group), the structural indices of the lumba r vertebral (L 1 and L 2) trabecular bone were assessed directly from 3 D image s. Results Treatment with alendronate increased bone volume fraction by 9.5％ a nd 7.7％ respectively, in the L 1 and L 2. Trabecular thickness significantly in creased after alendronate treatment, whereas trabecular separation remained cons tant. The degree of anisotropy for the alendronate treated group was decreased compared with that of the control group. Bone surface to volume ratio declined s ignificantly in the alendronate treated group, whereas alendronate induced a hi gher value of bone surface density. Conclusion Alendronate increased the struct ural properties of canine trabecular bone after short-term treatment at a dose of 0.5 mg?kg－1?d－1. Thus, alendronate could increase the structural properti es of healthy trabecular bone in a short-term period.
