Abnormality of growth regulatory factors in benign prostatic hyperplasia
- VernacularTitle:生长调控因子异常与良性前列腺增生的关系
- Author:
Qingxiang XIE
;
Hong WANG
;
Fudi LIN
- Publication Type:Journal Article
- Keywords:
Prostatic hyperplasia;
Growth factor;
Cell apoptosis
- From:
Chinese Journal of Urology
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of 15 kinds of growth regulatory factors in the pathogenesis of benign prostatic hyperplasia (BPH). Methods 15 kinds of growth regulatory factors involving cell proliferation and apoptosis were studied by immunohistochemistry with computer assisted quantitative image analysis.The mean percent area densities of stroma,epithelium and glandular lumen in BPH were examined by quantitative image analysis. Results Positive relations were found bewteen expressions of basic fibroblast growth factor (bFGF),transforming growth factor ?, fibronectin, type Ⅳ collagen and proportions of stroma (r=0.323?0.278?0.235?0.241,P
