The role of immune complex(IgG) and complement(C_(3c))in immunopathogenesis of ulcerative colitis
- VernacularTitle:免疫复合物IgG及补体C_(3c)在溃疡性结肠炎免疫发病机制中的作用
- Author:
Qijia LI
;
Min XU
;
Xueyi ZHANG
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis;
Immunoglobulin(IgG);
Complement(C 3c )
- From:
Clinical Medicine of China
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore new insight into the immunopathogenesis of ulcerative colitis.Methods Immunohistochemistry for the immunoglobulin(IgG)and complement(C 3c )was performed in biopsy specimens of the mucous membrane from 50 patients with ulcerative colitis(32 in active state and 18 in inactive state)and 5 controls.Results The immunoglobulin and activated complement were found in the epithelium mucosae and basement membrane of capillary walls in ulcerative colitis,with highest density in patients with active ulcerative colitis as compared with inactive ones.Conclusions The activation of immunoglobulin(IgG)and complement(C 3c )are closely related to active ulcerative colitis which plays an important role in the tissue damage of active ulcerative colits.Immunoglobulin(IgG)and complement(C 3c )are important components of immunoregulatory network of ulcerative colitis
