Expression of human vascular endothelial growth factor in ampullary carcinoma and its significance
- VernacularTitle:壶腹部癌组织血管内皮生长因子的表达及意义
- Author:
Yixiong ZHENG
;
Li CHEN
;
Sifeng TAO
- Publication Type:Journal Article
- Keywords:
immunohistochemistry;
ampullary neoplasms;
angiogenesis;
microvessel density;
prognosis
- From:
China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate the expression of VEGF and its prognostic significance in ampullary carcinoma.Methods:22 resected tumor specimens from patients with ampullary carcinoma were immunohistochemically stained for VEGF and CD34 (surrogate for vessels) by streptavidin-peroxidase (S-P) method. Results:Expression of VEGF in tumor tissue was found in 50% cases of patients with ampullary carcinoma. The mean MVD for the entire group was 26.4?12.8. A significantly higher MVD(35.0?9.6) was observed in the tumors with positive VEGF expression compared with tumors with negative VEGF expression(17.7?9.3)( P
