Expression of p27~(Kip1) and cyclin D1 in human gastric carcinoma and its prognostic significance
- VernacularTitle:p27~(Kip1)和细胞周期蛋白D1在胃癌中的表达及其预后意义
- Author:
Chuangui SONG
;
Huishan LU
;
Xiangfu ZHANG
- Publication Type:Journal Article
- Keywords:
gastric carcinoma;
p27 Kip1 gene;
cyclin D1;
prognosis;
immunohistochemistry
- From:
China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:This study was designed to investigate the expression of p27 Kip1 and cyclin D1 in gastric carcinoma in relation to biological behavior and prognosis. Methods:p27 Kip1 and cyclin D1 expression at protein level were determined by immunohistochemistry technique in 92 patients with gastric carcinoma. Results:Of the 92 patients, p27 Kip1 expression was low in 28(71.8%) and high in 11(12%),respectively. Cyclin D1 expression was low in 32 (72.7%) and high in 12 (13%) ,respectively.p27 Kip1 expression level was correlated with histological grade, depth of invasion, lymph-node metastasis, TNM stage( P
