STUDY OF THE ETIOLOGICAL SIGNIFICANCE OF HBV IN PRIMARY HEPATOCELLULAR CARCINOMA
- VernacularTitle:乙型肝炎病毒在原发性肝细胞癌中病原意义的研究
- Author:
Guangshu ZHANG
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma HBV infection Cause and effect relationship
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The clinical data and HE stain sections of 70 PHC cases and 7 bile-capillary carcinoma patients were reviewed. Victoria blue stain was used for all these liver samples,. Our observations showed that the detection rates of HBsAg in liver cells without a history of positive serum HBsAg test and either with serum HBsAg negative or positive were rather high, 85.7%. 75.0% and 90.2% respectively. There was no significant difference among them. It is worthy to note that HBsAg could be detected in liver cells sections with Victoria blue stain in 75.0% of liver samples whose serum HBsAg was negative. The positive rates of HBsAg in liver cells of serum HBsAg negative and positive patients were without obvious difference. It seemed to suggest that the posibility of HBV infection and its carcinogenic role could not be excluded in the serum HBsAg negative patient. In addition, HBsAg could be detected in the carcinoma cells in 34.3% of liver samples, and also in the abnormal cells between the carcinoma and liver tissue sections in 9.8% with Victoria blue stain. However, neither HBsAg could be found in all the 7 bile-capillary carcinoma sections with in Victoria blue stain, norground-glass cells could be seen in the HE stain sections. These results seemed to further prove that there might be a close cause and effect relationship between the HBV infection and PHC.
