Adervances in the research of multidrug resistance-associated protein's biological characters and mechanism
- VernacularTitle:多药耐药相关蛋白的生物学特性与作用机制的研究进展
- Author:
Zhaolu KONG
;
Yizun JIN
- Publication Type:Journal Article
- Keywords:
multidrug-resistance associated protein;
multidrug resistance;
ATP-binding cassette superfamily transporters
- From:China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Multidrug-resistance associated protein (MRP), a member of ATP-binding cassette superfamily transporters,confers multi-drug resistance by reducting intracellular drug concentrations and/or altering the pattern of intracellular drug distribution. Using mrp gene knockout models, researchers have found that a total block of mrp is compatible with life and its physiological functions seem to be an ATP-depending pump to co-transport free GSH and some presently unknown endogenous metabolites to protect the normal extracellular environment.
