Changes of thyroid weight and function after ~(131)I therapy for Graves′ disease
- VernacularTitle:Graves病~(131)I治疗后甲状腺重量和功能的变化
- Author:
Xinjian ZHOU
;
Fang LI
;
Qian ZHOU
- Publication Type:Journal Article
- Keywords:
Graves′ disease;
Radionuclide imaging;
Ultrasonography;
Iodine isotopes;
Thyroid weight
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe changes of thyroid weight and function after 131 I therapy in Graves′ diseaseandtooptimiseradiationdose for treatment of Graves′ disease. Methods From 1995 to 1998, 103 patients with Graves′ disease were selected (nodule was not found by palpation and nuclear scintigraphy). The mean age was 43 (range 27～64) years. Thyroid weight was estimated by nuclear scintigraph (SC) and ultrasound (US). Thyroid function was determined by serum TT 3, TT 4, FT 3, FT 4 and TSH levels. Results The oral dose of 131 I was (188.7?144.3)MBq. If the dose was larger than 555.0 MBq, it was divided into two doses orally. The thyroid weight of the patients before 131 I therapy was (54.8?32.3)g (SC) and (49.3?27.7)g (US), there was no significant difference between SC and US. The thyroid weight in 90 patients was significantly decreased from (51.5?23.4)g to (27.0?13.9)g by SC, and from (47.2?23.7)g to (20.6?8.4)g by US 6～7 months after 131 I treatment. Reduction of thyroid weight was correlated with that before therapy (determined by US) (r=0.49, P
