The relationship between large multifunctional proteasome 7 gene polymorphism and susceptibility of type 1 diabetes mellitus
- VernacularTitle:大多功能蛋白酶7基因多态性与1型糖尿病易感性的关系
- Author:
Helin DING
;
Hua CHENG
;
Zuzhi FU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, insulin dependent;
Polymerase chain reaction;
Polymorphism, restriction fragment length;
Gene, large multifunctional proteasome 7
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between large multifunctional proteasome (LMP) 7 gene polymorphism and susceptibility of type 1 diabetes mellitus (DM). Methods The genotyping of LMP7 gene was determined by polymerase chain reaction restriction fragment length polymorphism (PCR RFLP) in 71 type 1 DM patients and 86 healthy persons (as controls). Furthermore, the type 1 DM patients were divided into 3 groups according to the age of diabetic onset. Group A was ≤14 years, group B 15～30 years, group C≥31 years.Results The frequency of LMP7 B/B was decreased significantly (39% vs 58%, P
