Study on the relationship between N~( 5,10)-methylenetetrahydrofolate reductase gene polymorphism and the susceptibility to microangiopathy in type 2 diabetes mellitus
- VernacularTitle:亚甲基四氢叶酸还原酶基因多态性与2型糖尿病微血管病变易感性的研究
- Author:
Guoqing YANG
;
Juming LU
;
Changyu PAN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, non insulin dependent;
Diabetic nephropathies;
Diabetic retinopathy;
Polymorphism (Genetics);
Gene, methylenetetrahydrofolate reductase
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the polymorphism of N 5,10 methy lenetetrahydrofolate reductase (MTHFR) gene and the susceptibility to diabetic microangiopathy (DMAP) in type 2 diabetes mellitus (DM) of Han nationality in north China. Methods By PCR RFLP, MTHFR C677T mutation was detected in 229 type 2 diabetic patients, including 102 non complication diabetics (NCD group), 67 diabetic nephropathy (DN group) and 60 diabetic retinopathy (DR group), and 62 healthy persons as control (CON group). Results The frequency of homozygous BB genotype and allele B in DN and DR were significantly higher than that in NCD and CON, but NCD and COD showed similar frequency of BB genotype and allele B. Conclusion In type 2 DM of Han nationality in north China, there is a strong correlation between the polymorphism of MTHFR gene and DMAP, and the allele B may be a susceptibile gene of DMAP.
