PHARMACOKINETICS OF SODIUM COBALTINITRSTE
- VernacularTitle:抗氰剂亚硝酸钴钠的药物动力学
- Author:
Jianyao MAO
- Publication Type:Journal Article
- Keywords:
sodium cobaltinitrite potassium cyanide dimethyl sulfoxide methemoglobin pharmacokinetics
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
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Abstract:
in this paper we report the blood cobalt, methemoglobin and blood cyanide concentration-time equations and related parameters of pharmacokinetics after abministra-tion of sodium cobaltinitrite(18.6mg/kg)or potassium cyanide(3mg/kg)in dogs.It was found that 10% dimethyl sulfoxide used as a solvent, as compared with water, accelerated sodium cobaltinitrite absorption by intramuscular administration.The half absorption time was reduced from 14.5 min to 5.5 min, the time of maximum concentration of blood cobalt reduced from 1.11 h to 0.56 h, and the maximum conce-tration of blood cobalt raised from 2.71?g/ml to 3.35?g/ml.There was a significant difference of blood cobalt concentrasions between 10-60 and 120 min after intramuscular administration.
