Effects of Captopril on structure and function of sciatic nerve in diabetic rats
- VernacularTitle:卡托普利对糖尿病大鼠坐骨神经结构和功能的影响
- Author:
Guoliang SUI
;
Guoqing LIU
;
Yanhu DONG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, experimental;
Diabetic neuropathies;
Captopril
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of captopril on structure and function of sciatic nerve in diabetic rats. Methods Streptozotocin induced diabetic male Sprague Dawley rats were treated with 0.1% captopril in drinking water for 12 weeks, then advanced glycation end products (AGEs), cAMP content, and the nerve conduction velocity of sciatic nerve in diabetic rats were measured, morphometric quantitative analysis and ultrastructure of sural nerve were also performed. Results Captopril reduced accumulation of AGEs, restored synthesis of cAMP in sciatic nerve, improved nerve conduction velocity partialy, and ameliorated morphology abnormalities in myelin nerve fibre. Conclusion These findings suggest that captopril may exert a therapeutic effects on diabetic peripheral neuropathy.
