HLA-DQ polymorphism to myasthenia gravis susceptibility
- VernacularTitle:HLA-DQ基因多态性对重症肌无力遗传易患性的相关研究
- Author:
Keming DU
;
Jingsheng LIU
;
Kexiong ZHANG
- Publication Type:Journal Article
- Keywords:
Myasthenia gravis;
HLA DQ antigens;
Polymorphism(genetics);
Genetic predisposition to disease
- From:
Chinese Journal of Neurology
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the association HLA DQ gene polymorphism to MG susceptibility.Methods HLA DQA1 and DQB1 were genetyped using PCR RFLP Results Comparing the frequency of HLA DQA1 alleles between MG patients with hyperplasia or MG males with disease onset less than 30 years and the healthy controls It was found that the frequency of DQA1*0301 was significantly increased Furthermore,in comparison with the frequency of HLA DQB1 alleles between MG patients (included subgroups)and the healthy controls,the frequency of DQB1*0303 was significantly increased,while the frequencies of DQB1*0601 and DQB1*0602 were significantly decreased And these differences were statistically significant. Conclusions HLA DQA1*0301 contributes to the genetic susceptibility of MG with hyperplasia and MG males with disease onset ≤30 years old DQB1*0303 was susceptible to MG DQB1*0601 and DQB1*0602 were protective genes
