The use of sarcoglycan antibodies in diagnostic tests for sarcoglycanopathies
- VernacularTitle:基因产物检测诊断肌聚糖病五例报告
- Author:
Suobin WANG
;
Dingguo SHEN
- Publication Type:Journal Article
- Keywords:
Muscular dystrophies;
Membrane glycoproteins;
Sarcoglycanopathy;
Immunohistochemistry
- From:
Chinese Journal of Neurology
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the characteristics of sarcoglycanopathies and their diagnostic methods.Methods On basis of dystrophin immunostaining,the muscle specimens of 25 LGMD with normal dystrophin were investigated using all four sarcoglycan (?,?,?,? sarcoglycan) antibodies by immunohistochemistry and Western blotting. Results 5 specimens showed a deficiency: one case in ? SG,two in ? SG,one in three SG,and one in all four SG.Conclusion 5 patients were diagnosed as "sarcoglycanopathies". As it is difficult to distinguish the various types of LGMD based on clinical features,the immunohistochemistry and Western blotting of all four sarcoglycan antibodies may serve as an important diagnostic tool for sarcoglycanopathies.
