Effects of hyaluronan and hyaluronidase on proliferative scar formation during the wound healing in rabbit ear being injured
- VernacularTitle:透明质酸及透明质酸酶对兔耳创面增生性瘢痕形成影响的对比研究
- Author:
Xijun LI
;
Dalie LIU
;
Yang ZHANG
- Publication Type:Journal Article
- Keywords:
Wound healing;
Cicatrix;
Hyaluronan;
Hyaluronidase
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of hyaluronan (HA) and hyaluronidase (HAse) on the formation of hypertrophic scar in rabbit ear after injury. Methods Wound healing models were established on 18 adult rabbit ears, which were randomly divided into the HA treated group (Group A), the HAse treated group (Group B), the PBS treated group (Group C). The process of wound healing was observed grossly and histologically. The variation of the contents of hydroxyproline(HPr) at the stage of wound healing and post healing was measured. The relative height of scars were measured under microscope at the peaks of scar formation. Results ①The mean values of wound healing time of Group A, B and C was 11.7?0.6, 9.8?0.9, 10.8?1.0 days respectively. ②Compared with PBS controls and HAse treated group, the collagon fiber was slender and arranged in normal order in HA treated wound at early stage of wound healing. But there were no difference among them at the stage of scar formation. ③The contents of HPr were statistically lower in HA treated group than in controls at the stage of wound healing, but no difference at the stage of scar formation.The HPr contents in HAse treated group were higher than the others all the way. ④ The mean values of relative thickness of Group A, B and C were 1.55?0.35,1.89?0.39,1.59?0.29 respectively. Conclusion ①Exogenous HA on the wound surface can not affect the scar tissue proliferation;② HAse promotes the proliferation.
