MRI study on the hippocampal atrophy due to mild Alzheimer's disease
- VernacularTitle:轻度阿尔茨海默病海马萎缩的磁共振研究
- Author:
Weihong KUANG
;
Mingsheng HUANG
;
Jin LI
- Publication Type:Journal Article
- Keywords:
Hippocampus;
Alzheimer disease;
Magnetic resonance imgaging
- From:
Chinese Journal of Geriatrics
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the features of hippocampal atrophy (HA) by MRI in mild Alzheimer's disease(AD) patients. Methods Fifteen mild AD patients and 30 healthy controls were included in this study and all subjects were examined by both MRI and MMSE. The differences in the hippocampal volume between the mild AD and the control were analysed, and relationships between the hippocampal volume and age, MMSE scores were evaluated. Results The hippocampal volume of the mild AD was decreased significantly than that of the controls 〔(2 08?0 46)cm 3 vs (3 11?0 19)cm 3, t =2 71, P 0 05). Conclusions MRI-based HA could be used to differentiate the mild AD patients effectively from the healthy subjects and could also be regarded as a status marker for the early clinical diagnosis of AD.
