Immunohistochemical study of the effects of interlenkin 6 and tumor necrosis factor-? on vertebral bone in senile osteoporosis
- VernacularTitle:老年骨质疏松症患者腰椎白细胞介素-6、肿瘤坏死因子-?的免疫组化研究
- Author:
Hongbin FAN
;
Quanping WANG
- Publication Type:Journal Article
- Keywords:
Interleukin 6;
Tumor necrosis factor;
Osteoporosis
- From:
Chinese Journal of Geriatrics
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of interleukin 6 (IL 6) and tumor necrosis factor ? (TNF ?) , location of both cytokines and their relationship with the variation of bone mineral density (BMD). Methods Cancellous bone chips were obtained from the vertebral bone of senile osteoporosis and control subjects during operation. Slides were made and stained with IL 6 and TNF ? monoclonal antibody, respectively. Results Osteoblasts and stromal cells were strongly positive to IL 6 and TNF ? in osteoporosis groups. The number of positive cells in high power field are 107 9?42 6 and 99 0?31 8 in osteoporosis groups, and 31 4?20 5 and 28 5?17 1 in controls, respectively, showing significant difference between two groups ( P
