Optimum Dose of Pipecuronium with a Intravenous Bolus Injection for Endotracheal Intubation in Adults.
10.4097/kjae.1997.33.3.453
- Author:
Tae Gan RYU
;
Mi Kyeong LEE
;
Young Cheol PARK
;
Sang Ho LIM
;
Suk Min YOON
;
Young Seok CHOI
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Neuromuscular relaxants, pipecuronium;
Intubation, tracheal, conditions
- MeSH:
Adult*;
Anesthesia;
Animals;
Autonomic Nervous System;
Blood Pressure;
Heart Rate;
Hemodynamics;
Histamine Release;
Humans;
Intubation;
Intubation, Intratracheal*;
Neuromuscular Blockade;
Nitrous Oxide;
Pipecuronium*;
Ulnar Nerve
- From:Korean Journal of Anesthesiology
1997;33(3):453-457
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Studies in animals suggest that pipecuronium dose not induce hemodynamic chan-ges related to histamine release or to an effect on the autonomic nervous system. Therefore the effects of bolus administration of large doses of pipecuronium, up to 0.20 mg/kg, on the intubation condition, onset and duration of neuromuscular blockade, heart rate and blood pressure were studied during fentanyl- nitrous oxide anesthesia. METHOD: Forty adults were randomly assigned to receive a bolus injection of either 0.05, 0.10, 0.15, 0.20 mg/kg of pipecuronium. Neuromuscular blockade was measured using mechanomyographic activity of the adductor pollicis muscle after supramaximal stimulation of the ulnar nerve. Four subgroups of 10 patients received pipecuronium doses of 0.05, 0.10, 0.15 and 0.20 mg/kg, respectively, as an intubating dose. RESULTS: The times of onset and clinical duration (mean sem) after each dose were as follows: 0.05 mg/kg, 2.98 0.42 and 41.5 2.42 min; 0.10 mg/kg, 1.54 0.06 and 82.9 7.48 min; 0.15 mg/kg, 1.41 0.14 and 124.8 13.1 min; 0.20 mg/kg, 1.12 0.05 and 187.1 12.8 min. The intubation condition, time of onset and duration after doses of 0.05 mg/kg were significantly different from values after the higer doses. The duration was increased with dose-increments. No dose-related changes in heart rate or blood pressure were observed. CONCLUSION: The authors conclude that dose of 0.10 mg/kg and over has good intubation condition clinically and large bolus dose of pipecuronium can be safely used with a significantly prolonged duration of action without hemodynamic change.
