The study of PAI-1 promotor region gene polymorphism in cerebrovascular disease
- VernacularTitle:PAI-1启动子区4G/5G基因多态性与脑血管病相关性研究
- Author:
Chen ZHANG
;
Jiang LI
;
Bing LUO
- Publication Type:Journal Article
- Keywords:
Cerebrovascular disease Plasminogen activator inhibitor Polymorphism
- From:
Chinese Journal of Immunology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the plasminogen activator inhibitor 1(PAI 1) gene polymorphism and cerebrovascular disease and whether it played an important role in the pathogenesis of cerebrovascular disease Methods:The 4G/5G allele polymorphism in the PAI 1 gene promotor region were genotyped by polymerase chain reaction (PCR) from peripheral blood leukocytes from 60 normal controls, 65 patients with acute cerebral infarction and 31 hypertensives complicated with cerebral hemorrhage Their plasma PAI 1 activity were assayed by ELISA Results: The plasma PAI 1 activity level in the CI group was significantly higher than those in the other two groups PAI 1 level was significantly higher in 4G allele homozygous than both those in 4G/5G heterozygous and 5G homozygous Although PAI 1 level was higher in 4G/5G heterozygous than that in 5G homozygous, the difference had not reach statistically significant There were significant differences between acute cerebral infarction PAI 1 gene polymorphism and controls (P0 05), and PAI 1 levels of the 4G/4G genotype among female patients with CI were higher than those of the male patients with CI of the same genotype Conclusion: The results suggest that PAI 1 gene polymorphism may be a susceptible factor to acute cerebral infarction in Chinese, and 4G allele homozygous genotype may be the major risk factor of acute cerebral infarction, especially it may be an independent risk factor of female CI patients
