Expression of p27~(kip1) in prostatic intraepithelial neoplasia cells
- VernacularTitle:p27~(kip1)在前列腺上皮内瘤细胞中的表达
- Author:
Dingwei YE
;
Hui LI
;
Land RICHARD
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Cell cycle
- From:
Chinese Journal of Urology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of p27 kip1 protein in prostatic intraepithelial neoplasia cells. Methods In 22 human prostatic samples, the expression of p27 kip1 protein in high grade prostatic intraepithelial neoplasia cells was evaluated by using immunohistochemical analysis. Results The expression of p27 kip1 in prostatic intraepithelial neoplasia cells was weaker than in adjacent prostatic epithelial cells in all the 22 prostate samples. Conclusions Decrease of the p27 kip1 expression may play a role in the development of PIN which may be an premalignant lesion.
