Expression of matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinase-1(TIMP-1) in gastric carcinoma
- VernacularTitle:基质金属蛋白酶-9、组织金属蛋白酶抑制因子-1在胃癌中的表达
- Author:
Yanming ZHOU
;
Yumin LI
;
Feng ZENG
;
Youquan ZHU
- Publication Type:Journal Article
- Keywords:
Stamach neoplasms;
Metalloproteinases;
Tissue inhibitor of metalloproteinases;
Gene expression
- From:
Chinese Journal of Current Advances in General Surgery
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the expression and significance of MMP-9 and TIMP-1 in gastric carcinoma.Methods: S-P immunohistochemical method was used to examine the expression of MMP-9 and TIMP-1 in 47 specimens of gastric carcinoma.Results: MMP-9 and TIMP-1 were expressed predominantaly in the peritumor stromal cells than tumor cells themselves.The expression level of MMP-9 and TIMP-1 correlated with lymph node metastasis (P0 05).Conclusion: The results suggests that MMP-9 and TIMP-1 might be important biological makers for determining the malignant behave of gastric carcinoma.
