Comparison of efficacy between Glipizide GITS and Gliclazide in the treatment of Chinese patients with type 2 diabetes mellitus
- VernacularTitle:控释格列吡嗪与格列齐特治疗中国2型糖尿病患者的疗效比较
- Author:
Changyu PAN
;
Yan GAO
;
Guangwei LI
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, non insulin dependent;
Glipizide;
Gliclazide;
Delaged action preporations
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical efficacy of once daily regimen with Glipizide GITS (Glucotrol XL) and multiple dose regimen with Gliclazide (Diamicron) in the treatment of Chinese patients with type 2 diabetes mellitus. Methods One hundred and fifty one Chinese type 2 diabetic patients meeting the 1985 WHO diagnostic criteria were recruited from 4 clinical centers. The patients were assigned to Glipizide GITS (78 cases) or Gliclazide (73 cases) treatment group. Results The trial consisted of 1 week washout period followed by 6 week dosage regulation period and 6 week dosage maintenance period. Comparing to the baseline, HbA 1c , fasting plasma glucose (FPG) and 24 hour glucose profile levels in two groups were significantly reduced after 3 month treatment. In Glipizide GITS group, the mean reductions of blood HbA 1c and FPG level were 0.55% and 2.05 mmol/L respectively (P
